Year: 2025

Mechanistic Analysis of a Mixed-Function Polysaccharide Lyase/Epimerase from the Human Gut Microbiota

by
Mechanistic Analysis of a Mixed-Function Polysaccharide Lyase/Epimerase from the Human Gut Microbiota

ClickBlueWords to Follow Us Hello everyone, the article we are sharing today is titled “The Swiss Army Knife of Alginate Metabolism: Mechanistic Analysis of a Mixed-Function Polysaccharide Lyase/Epimerase of the Human Gut Microbiota,” published in 2025 in the Journal of the American Chemical Society. Alginate is an important marine polysaccharide primarily found in the cell … Read more

How WQ Microelectronics Ranks Among the Top Five Bluetooth SoC Chip Manufacturers: Decoding the Breakthrough of Domestic Chips

by
How WQ Microelectronics Ranks Among the Top Five Bluetooth SoC Chip Manufacturers: Decoding the Breakthrough of Domestic Chips

In recent years, with the explosive growth of TWS (True Wireless Stereo) headphones, smart wearables, and IoT devices, the Bluetooth SoC chip market has experienced rapid development. Giants like Qualcomm, MediaTek, Hengxuan, and Rockchip dominate the market, but a Chinese chip company—WQ Microelectronics—has quietly entered the top five global Bluetooth SoC chip manufacturers. In the … Read more

Dual Evolutionary Pathways of Genomic Structural Diversity in High-Grade Serous Ovarian Cancer (HGSOC) and Their Impact on Patient Prognosis

by
Dual Evolutionary Pathways of Genomic Structural Diversity in High-Grade Serous Ovarian Cancer (HGSOC) and Their Impact on Patient Prognosis

Recent studies reveal a “dual evolutionary” pattern in pancreatic cancer similar to that of ovarian cancer: the HRD pathway is primarily characterized by DNA deletions, while the WGD pathway drives tumor malignancy through chromosomal fragmentation and ecDNA amplification. Key findings include that mitochondrial mutations significantly affect prognosis (with a hazard ratio of 3.1), and CDK12 … Read more

Xinchip Technology and Richtek Collaborate on In-Vehicle SoC Reference Design to Achieve High-Performance, Miniaturized Smart Cockpit Systems

by
Xinchip Technology and Richtek Collaborate on In-Vehicle SoC Reference Design to Achieve High-Performance, Miniaturized Smart Cockpit Systems

Xinchip Technology and analog IC design company Richtek have jointly launched the “SD210” reference design aimed at smart cockpits. This reference design is based on Xinchip’s X9 series smart cockpit SoC chips and incorporates Richtek’s SoC PMIC RTQ2209 and other products, fully meeting diverse power supply requirements and aiding in the realization of high-performance, miniaturized … Read more

J. Am. Chem. Soc. | Jilin University’s Jiang Shimei: Achieving High-Performance Single-Component Adhesives through Synergistic Supramolecular and Covalent Polymerization

by
J. Am. Chem. Soc. | Jilin University’s Jiang Shimei: Achieving High-Performance Single-Component Adhesives through Synergistic Supramolecular and Covalent Polymerization

Adhesive research is an important topic in the field of chemistry, driving advancements across multiple industries from medicine and electronics to construction and automotive. Compared to traditional polymer adhesives, supramolecular adhesives represent an innovative approach that utilizes non-covalent interactions such as van der Waals forces, hydrogen bonding, π-π interactions, and hydrophilic/hydrophobic effects to achieve strong … Read more

Literature Sharing | J Am Chem Soc: Quantitative Analysis of Single-Cell High-Throughput Multi-Omics Aptomics

by
Literature Sharing | J Am Chem Soc: Quantitative Analysis of Single-Cell High-Throughput Multi-Omics Aptomics

High-throughput sequencing technology is driving the life sciences towards a quantitative paradigm, but the sequencing technologies for antibodies, glycans, and other non-directly measurable molecules face challenges such as complex coupling steps, steric hindrance, and the labor-intensive nature of enzymatic chemical labeling. Aptamers, as nucleic acid molecules that can be sequenced directly, possess high specificity, broad … Read more

The Battle of Smart Glasses: How Optical Displays, SoCs, Sensors, and Other Key Industry Chains Seize Opportunities

by
The Battle of Smart Glasses: How Optical Displays, SoCs, Sensors, and Other Key Industry Chains Seize Opportunities

Industry weatherman 产业气象员 The rapid development of artificial intelligence technology is profoundly reshaping the landscape of the consumer electronics industry. Smart glasses, as one of the most promising carriers for AI transformation, are gradually moving from concept to large-scale commercial application. With the gradual enhancement of AI model capabilities, human-computer interaction methods are undergoing revolutionary … Read more

Persistent Pulmonary Fibrosis Changes in Severe COVID-19 Patients Three Years Later

by
Persistent Pulmonary Fibrosis Changes in Severe COVID-19 Patients Three Years Later

On July 1, Columbia University’s Christine Kim Garcia published a paper in the Ann Am Thorac Soc regarding post-COVID sequelae titled “Imaging, Pulmonary Function, and Histopathologic Findings of Persistent Fibrosis in a Longitudinal Cohort 3-Years after COVID-19.” This study systematically reveals the long-term evolution of pulmonary fibrosis caused by the coronavirus through a three-year follow-up … Read more

Single-Molecule Reactor Based on the Excluded Volume Effect of Bottlebrush Polymers

by
Single-Molecule Reactor Based on the Excluded Volume Effect of Bottlebrush Polymers

Hello everyone, today I would like to share a recently published article in J. Am. Chem. Soc. titled Single-Molecule Reactor Based on the Excluded Volume Effect of Bottlebrush Polymers. The corresponding author of the article is Professor Shintaro Nakagawa from the University of Tokyo. Living organisms rely on various chemical reactions to sustain life, which … Read more

RNA-Activated CRISPR/Cas12a Nanorobots Operating in Live Cells

by
RNA-Activated CRISPR/Cas12a Nanorobots Operating in Live Cells

Abstract The active clustered regularly interspaced short palindromic repeats (CRISPR/Cas12a) system possesses cis-cleavage (targeting) and trans-cleavage (off-target) activities, which are highly useful for genome engineering and diagnostic applications. Both single-stranded and double-stranded DNA can activate crRNA−Cas12a ribonucleoprotein (RNP), enabling its cis and trans cleavage enzymatic activities. However, whether RNA can activate the CRISPR/Cas12a system and … Read more