Source: Yunqi IVD Original Title: Comprehensive Analysis of Molecular Diagnosis Technology (Part 1, Part 2, Part 3) Part 1 Molecular diagnosis technology uses molecular biology methods to detect the expression and structure of genetic material from the human body and various pathogens, thereby achieving the purpose of predicting and diagnosing diseases. In recent years, with … Read more
Click the arrow to follow us on the “In Vitro Diagnostic POCT Forum”! Molecular diagnosis is a method and process that uses DNA, RNA, or protein molecules as diagnostic materials to specifically diagnose the state of the human body or diseases by examining the presence, defects, or abnormal expression of endogenous genes or exogenous (pathogen) … Read more
Scan to follow our official account↓↓↓ Have opinions, have attitudes This is the 615-1 article of the Medical Industry Observation official account Introduction: The GeneXpert PCR analyzer is a flagship product of Danaher’sCepheid company. Today, we will introduce you to the development history ofCepheid and its products. Let’s first appreciate the elegance ofGeneXpert: The machine … Read more
Source: IVD Practitioner Network Author: Suo Yan Molecular diagnostics of genetic nucleic acids is driven by the needs of modern life sciences, utilizing various advanced manufacturing and instrumentation technologies to develop detection instruments. It combines various testing techniques, analytical techniques, and scientific principles from other foundational disciplines to qualitatively and quantitatively observe, compare, analyze, and … Read more
DNA methylation is one of the earliest discovered forms of gene epigenetic modification. In eukaryotes, methylation occurs only at cytosine, where DNA methyltransferases (DNMTs) convert the 5′ end cytosine of CpG dinucleotides to 5′-methylcytosine. Numerous studies have shown that DNA methylation can induce changes in chromatin structure, DNA conformation, DNA stability, and the interaction patterns … Read more
In a previous article, we discussed the prediction of CpG islands. Once a CpG island is identified, it is necessary to detect the methylation status of the corresponding region. There are various methods to detect methylation status, but the currently recognized gold standard is the bisulfite sequencing PCR (BSP). BSP Principle Genomic DNA is treated … Read more
Open source hardware solutions can contribute to combating the spread and suffering caused by the novel coronavirus. — Harris Kenny The open source hardware movement has long advocated for the importance of the right to repair, fully owning the technology purchased, and being able to recombine and replicate parts like music. Therefore, during this challenging … Read more