DNA methylation is one of the earliest discovered forms of gene epigenetic modification. In eukaryotes, methylation occurs only at cytosine, where DNA methyltransferases (DNMTs) convert the 5′ end cytosine of CpG dinucleotides to 5′-methylcytosine. Numerous studies have shown that DNA methylation can induce changes in chromatin structure, DNA conformation, DNA stability, and the interaction patterns … Read more
In a previous article, we discussed the prediction of CpG islands. Once a CpG island is identified, it is necessary to detect the methylation status of the corresponding region. There are various methods to detect methylation status, but the currently recognized gold standard is the bisulfite sequencing PCR (BSP). BSP Principle Genomic DNA is treated … Read more
Open source hardware solutions can contribute to combating the spread and suffering caused by the novel coronavirus. — Harris Kenny The open source hardware movement has long advocated for the importance of the right to repair, fully owning the technology purchased, and being able to recombine and replicate parts like music. Therefore, during this challenging … Read more