palladium catalysis

Palladium-Catalyzed Site– and Enantiodifferentiating Allylic C–H Alkylation of Internal Alkenes

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Palladium-Catalyzed Site– and Enantiodifferentiating Allylic C–H Alkylation of Internal Alkenes

Professor Liu-Zhu Gong’s team at the University of Science and Technology of China reported a site- and enantioselective allylic C–H alkylation of internal alkenes catalyzed by pocket-like chiral phosphoramidite-Pd. This method is applicable to a wide range of cyclic and acyclic internal alkenes. Abstract The site- and enantioselective transformation of allylic C-H bonds in ubiquitous … Read more

A New Non-Toxic Acetylation Reaction of Aryl Bromides Without Stille Coupling

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A New Non-Toxic Acetylation Reaction of Aryl Bromides Without Stille Coupling

Aryl methyl ketones are very useful organic synthesis intermediates. The traditional method introduces the acetyl group directly through Friedel-Crafts acylation, but this method requires an electron-rich aromatic ring to proceed smoothly. Another method involves the reaction of derivatives of aryl carboxylic acids (such as the commonly used reagent – Weinreb amide) with organometallic reagents to … Read more

Photoinduced Decarboxylative Allylation: Dual Atom Substitution for sp3 Fragment Skeleton Editing

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Photoinduced Decarboxylative Allylation: Dual Atom Substitution for sp3 Fragment Skeleton Editing

Image source: J. Am. Chem. Soc.Introduction:Professor Ruben Martin reported a photoinduced palladium-catalyzed interceptive decarboxylative allylation reaction. This strategy innovatively achieves atom pair exchange and a series of skeletal contraction and extension reactions, providing a non-traditional retrosynthetic approach for complex molecule construction, while offering a modular and versatile synthetic tool for rapidly and efficiently obtaining sp3 … Read more