A New Non-Toxic Acetylation Reaction of Aryl Bromides Without Stille Coupling
Aryl methyl ketones are very useful organic synthesis intermediates. The traditional method introduces the acetyl group directly through Friedel-Crafts acylation, but this method requires an electron-rich aromatic ring to proceed smoothly. Another method involves the reaction of derivatives of aryl carboxylic acids (such as the commonly used reagent – Weinreb amide) with organometallic reagents to … Read more