Neuroinflammation

Blocking the C/EBPβ-Fcgr1 Regulatory Axis Inhibits Microglial Pyroptosis and Improves Neurological Recovery

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Blocking the C/EBPβ-Fcgr1 Regulatory Axis Inhibits Microglial Pyroptosis and Improves Neurological Recovery

PMID: 39891259 DOI: 10.1186/s12974-024-03171-yIF: 11.7 Q1 Abstract CAAT/Enhancer Binding Protein β (C/EBPβ) is associated with the inflammatory response in neurodegenerative diseases, particularly in the brain. However, the regulatory role of C/EBPβ in spinal cord injury (SCI) and its impact on neurological recovery remain unknown. In this study, the research team observed a significant upregulation of … Read more

Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

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Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

PMID:37488863 DOI:10.4103/1673-5374.375343 Abstract Research indicates that microglia and macrophages participate in the multifaceted brain injury repair process following intracerebral hemorrhage (ICH). The E26 transformation-specific sequence-related transcription factor Spi1 regulates the polarization and maturation of microglia/macrophages. However, the role of Spi1 in ICH is unclear. In this study, the researchers found that Spi1 may regulate the … Read more