Macrophages

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA

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Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre-mRNA

Article Highlights RNA-binding proteins regulate post-transcriptional gene translation, but the macrophage-specific role of Zc3h12c remains unclear. Here, we characterized the role of Zc3h12c in macrophages using Tnfrsf11aCre-Zc3h12cflox/flox mice. Both Tnfrsf11a and Zc3h12c are highly expressed in renal tissues of patients with chronic kidney disease and are positively correlated with interstitial fibrosis scores. Single-cell RNA sequencing … Read more

Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

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Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

PMID:37488863 DOI:10.4103/1673-5374.375343 Abstract Research indicates that microglia and macrophages participate in the multifaceted brain injury repair process following intracerebral hemorrhage (ICH). The E26 transformation-specific sequence-related transcription factor Spi1 regulates the polarization and maturation of microglia/macrophages. However, the role of Spi1 in ICH is unclear. In this study, the researchers found that Spi1 may regulate the … Read more