Neuroimmunology Insights | Aβ/Tau Neural Circuits; Retrieval of Conditional Immune Response in Anterior-Posterior Insula; CD83+ Microglia

Neuroimmunology Insights | Aβ/Tau Neural Circuits; Retrieval of Conditional Immune Response in Anterior-Posterior Insula; CD83+ Microglia

1. Mol Psychiatry | Synaptic Vulnerability to β-Amyloid and Tau Pathologies Differentially Disrupts Emotional and Memory Neural Circuits Research Background: The core symptoms of Alzheimer’s Disease (AD) include memory loss and neuropsychiatric abnormalities (such as anxiety), with pathological markers being amyloid beta (Aβ) plaques and tau neurofibrillary tangles in the brain. However, how Aβ and … Read more

Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

Spi1 Regulates Inflammatory Response of Microglia/Macrophages After Intracerebral Hemorrhage via PI3K/AKT/mTOR Pathway

PMID:37488863 DOI:10.4103/1673-5374.375343 Abstract Research indicates that microglia and macrophages participate in the multifaceted brain injury repair process following intracerebral hemorrhage (ICH). The E26 transformation-specific sequence-related transcription factor Spi1 regulates the polarization and maturation of microglia/macrophages. However, the role of Spi1 in ICH is unclear. In this study, the researchers found that Spi1 may regulate the … Read more