Natural Products

Wageningen University Chem Soc Rev Paper | Integrating Genomics and Metabolomics to Map Specialized Metabolic Diversity

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Wageningen University Chem Soc Rev Paper | Integrating Genomics and Metabolomics to Map Specialized Metabolic Diversity

Wageningen University Chem Soc Rev Paper | Integrating Genomics and Metabolomics to Map Specialized Metabolic Diversity Wageningen University Chem Soc Rev Paper | Integrating Genomics and Metabolomics to Map Specialized Metabolic Diversity 1. Paper Introduction 2. Paper Abstract 3. Introduction 4. Genome Mining 5. Metabolomics Mining 6. Integration of Metagenomics 7. Opportunities 1. Paper Introduction … Read more

Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation

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Stereodivergent Synthesis of Allylic All-Carbon Quaternary Centers by Bimetallic Iridium/Magnesium-Catalyzed Allylic Alkylation

The research team led by Liu Yangbin from Peking University and Feng Xiaoming from Sichuan University optimized conditions using benzothiazole acetamide and trisubstituted allylic carbonates, successfully applying the “iridium/magnesium cooperative catalysis strategy” to the asymmetric allylic alkylation reaction of trisubstituted allylic electrophiles with non-cyclic nucleophiles (α-benzothiazole acetamide). Abstract The stereodivergent synthesis of structural motifs bearing … Read more

Professor Lu Zhaohong’s Research Group Achieves New Progress in the Total Synthesis of Complex Diterpenoid Natural Products

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Professor Lu Zhaohong's Research Group Achieves New Progress in the Total Synthesis of Complex Diterpenoid Natural Products

Research Updates Recently, Professor Lu Zhaohong’s research group has made new progress in the total synthesis of complex diterpenoid natural products, with the related research results published in the Journal of the American Chemical Society as “Enantioselective Total Synthesis of Bipolarolides A and B” (DOI: 10.1021/jacs.5c09835). Bipolarolides A and B are novel diterpenoid compounds derived … Read more

Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining

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Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining

Click the “Nanjing IFB” above to follow us! Hello everyone, today I would like to share an article published inJACS titled:Uncovering the Molecular Landscape of Tetracycline Family Natural Products through Bacterial Genome Mining. The corresponding author is Researcher Guohui Pan from the Institute of Microbiology, Chinese Academy of Sciences.Researcher Guohui Pan’s research focuses on the … Read more

Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for D‑Glutamic Acid and a Cryptic N‑Acylation Step During Pyrazole Core Formation

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Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for D‑Glutamic Acid and a Cryptic N‑Acylation Step During Pyrazole Core Formation

Click the “Nanjing University IFB” above to follow us! Hello everyone, today I would like to share a recent article published in the Journal of the American Chemical Society:Revision of the Formycin A and Pyrazofurin Biosynthetic Pathways Reveals Specificity for D‑Glutamic Acid and a Cryptic N‑Acylation Step During Pyrazole Core Formation, with the corresponding author … Read more

Biosynthesis of Dothideomins Reveals a Fungal P450 That Constructs the Tricyclo[5.2.2.0.4,8]undecane-Imbedded Core Skeleton

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Biosynthesis of Dothideomins Reveals a Fungal P450 That Constructs the Tricyclo[5.2.2.0.4,8]undecane-Imbedded Core Skeleton

Click the “Nanjing IFB” above to follow us! Hello everyone, today I would like to share a recent article published in theJACS journal titled “Biosynthesis of Dothideomins Reveals a Fungal P450 That Constructs the Tricyclo[5.2.2.0.4,8]undecane-Imbedded Core Skeleton”, with Professor Li Dehai from the School of Medicine, Ocean University of China as the corresponding author, who … Read more