Ischemia-Reperfusion Injury

Compilation of Cardiovascular Literature | IF>15 | 25.11.06-11.09

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Hypothyroidism, Atherosclerosis, and Cardiovascular Risk Prevention Journal: Nat Rev EndocrinolPMID: 41198906 Abstract: Hypothyroidism affects approximately 5% of the population and is associated with an increased risk of cardiovascular disease (CVD). This review explores the complex relationship between hypothyroidism and cardiovascular risk factors, analyzes the molecular mechanisms that accelerate atherosclerosis, and discusses risk assessment and personalized … Read more

Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (IRI) is a complex pathophysiological process that underlies persistent cardiac damage during cardiac surgery, heart transplantation, myocardial infarction, and cardiac arrest. During myocardial ischemia, the reduction in oxygen supply leads to a shift from fatty acid metabolism to anaerobic glycolysis, resulting in lactic acidosis that significantly decreases extracellular and intracellular pH to … Read more