Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury
Myocardial ischemia-reperfusion injury (IRI) is a complex pathophysiological process that underlies persistent cardiac damage during cardiac surgery, heart transplantation, myocardial infarction, and cardiac arrest. During myocardial ischemia, the reduction in oxygen supply leads to a shift from fatty acid metabolism to anaerobic glycolysis, resulting in lactic acidosis that significantly decreases extracellular and intracellular pH to … Read more