ASIC1a

Smooth Muscle Acid-Sensing Ion Channel 1a as a Therapeutic Target to Reverse Hypoxic Pulmonary Hypertension

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Smooth Muscle Acid-Sensing Ion Channel 1a as a Therapeutic Target to Reverse Hypoxic Pulmonary Hypertension

Acid-sensing ion channel 1a (ASIC1a) is a voltage-independent, non-selective cation channel that simultaneously conducts Na+ and Ca2+. The activation of ASIC1a causes depolarization of the plasma membrane, stimulating Ca2+-dependent signaling pathways in various cell types, including vascular smooth muscle (SM) and endothelial cells (ECs). Previous studies have indicated that the increase in pulmonary vascular resistance … Read more

Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (IRI) is a complex pathophysiological process that underlies persistent cardiac damage during cardiac surgery, heart transplantation, myocardial infarction, and cardiac arrest. During myocardial ischemia, the reduction in oxygen supply leads to a shift from fatty acid metabolism to anaerobic glycolysis, resulting in lactic acidosis that significantly decreases extracellular and intracellular pH to … Read more