Cardiac Function

Chen Wei: Application of Percutaneous Left Ventricular Reconstruction in Ischemic Heart Failure

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Chen Wei: Application of Percutaneous Left Ventricular Reconstruction in Ischemic Heart Failure

The five-year survival rate for heart failure is comparable to that of breast cancer and colorectal cancer. End-stage patients not only suffer from a significantly reduced quality of life but also impose a substantial economic and psychological burden on their families. Despite decades of research and development leading to the introduction of heart failure medications … Read more

Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (IRI) is a complex pathophysiological process that underlies persistent cardiac damage during cardiac surgery, heart transplantation, myocardial infarction, and cardiac arrest. During myocardial ischemia, the reduction in oxygen supply leads to a shift from fatty acid metabolism to anaerobic glycolysis, resulting in lactic acidosis that significantly decreases extracellular and intracellular pH to … Read more