TRK inhibitors

Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

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Therapeutic Inhibition of Acid Sensing Ion Channel 1a Recovers Heart Function After Ischemia-Reperfusion Injury

Myocardial ischemia-reperfusion injury (IRI) is a complex pathophysiological process that underlies persistent cardiac damage during cardiac surgery, heart transplantation, myocardial infarction, and cardiac arrest. During myocardial ischemia, the reduction in oxygen supply leads to a shift from fatty acid metabolism to anaerobic glycolysis, resulting in lactic acidosis that significantly decreases extracellular and intracellular pH to … Read more

VICTORIA Study: Larotrectinib vs Traditional SoC Efficacy Highlights

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VICTORIA Study: Larotrectinib vs Traditional SoC Efficacy Highlights

Due to the involvement of NTRK gene fusions in various tumors, their occurrence is rare, and the standard therapies (SoC) and prognoses for different tumors vary. Conducting clinical trials of TRK inhibitors using the “gold standard” randomized controlled trials (RCTs) is often impractical. Currently, clinical trials for TRK inhibitors mostly employ single-arm basket study designs … Read more