metabolic engineering

Biosensor Exploration: Enhancing L-Threonine Production in Escherichia coli

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Biosensor Exploration: Enhancing L-Threonine Production in Escherichia coli

L-Threonine is an essential amino acid with high demand in the feed, food, and pharmaceutical industries. Although systematic metabolic engineering has enabled Escherichia coli to produce L-threonine at a concentration exceeding 120 g/L, achieving both high yield and productivity remains challenging due to the complexity of the metabolic network and the difficulty in identifying targets. … Read more

Progress in High-Throughput Screening Research Based on Small Molecule Sensors for Actinomycetes

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Progress in High-Throughput Screening Research Based on Small Molecule Sensors for Actinomycetes

Actinomycetes can produce a wide variety of secondary metabolites, and microbial fermentation is an important means for obtaining these natural products. For a specific target product, the yield from wild strains is generally insufficient to meet industrial production requirements, necessitating long-term strain domestication to enhance yield. The combination of small molecule biosensors and droplet microfluidics … Read more