The Future of PROTACs and Molecular Glue: E3 Ligand Development Overview
This article combines literature and patents to introduce the recent development status of new E3 ligands. First, let’s talk about DCAF1. Biological Background of DCAF1 DCAF1 (also known as VprBP) is a multifunctional E3 ubiquitin ligase substrate receptor that participates in the regulation of various cellular processes. It is part of the Cullin-RING ligase (CRL) … Read more