brain metastases

Breakthroughs in HER2-Targeted ADCs for Treating Brain Metastases in Lung Cancer: Clinical Progress from DS-8201 to SHR-A1811

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Breakthroughs in HER2-Targeted ADCs for Treating Brain Metastases in Lung Cancer: Clinical Progress from DS-8201 to SHR-A1811

Abstract: Brain metastases (BMs) from lung cancer are one of the major factors contributing to poor prognosis in patients with non-small cell lung cancer (NSCLC). In recent years, antibody-drug conjugates (ADCs) have emerged as a new hope for treating HER2-mutant NSCLC due to their precise targeting and potent anti-tumor activity. This article focuses on the … Read more

Recent Advances in ADC Therapy for Active Brain Metastases in Breast Cancer

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Recent Advances in ADC Therapy for Active Brain Metastases in Breast Cancer

Brain metastases are a common and severe complication of metastatic breast cancer (MBC), with approximately 20% to 30% of patients experiencing brain metastases[1]. Among these, the incidence of brain metastases in HER2-positive MBC patients can reach 30% to 55%[2]; the incidence is also high in HER2-negative patients[3]. This makes MBC the second leading cause of … Read more

Recent Advances in ADC Therapy for Active Brain Metastases in Breast Cancer

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Recent Advances in ADC Therapy for Active Brain Metastases in Breast Cancer

Brain metastases are a common and severe complication of metastatic breast cancer (MBC), with approximately 20% to 30% of patients experiencing brain metastases[1]. Among these, the incidence of brain metastases in HER2-positive MBC patients can reach 30% to 55%[2]; the incidence is also high in HER2-negative patients[3]. This makes MBC the second leading cause of … Read more

Progression-Free Survival Increased Fivefold, Intracranial Response Rate at 65.7%! ‘Miraculous Anti-Cancer Drug’ Solves the Treatment Challenge of Breast Cancer Brain Metastases

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Progression-Free Survival Increased Fivefold, Intracranial Response Rate at 65.7%! 'Miraculous Anti-Cancer Drug' Solves the Treatment Challenge of Breast Cancer Brain Metastases

What else can DS-8201 not do? Recently, the “miraculous anti-cancer drug” DS-8201 announced data from its DESTINY-Breast03 trial involving patients with brain metastases[1]: Among 43 patients with HER2-positive breast cancer brain metastases treated with DS-8201, the median progression-free survival reached 15.0 months, with intracranial objective response rate and overall objective response rate at 65.7% and … Read more

Clinical Research Confirms DS-8201 Effectively Treats Brain Metastases from Breast Cancer

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Clinical Research Confirms DS-8201 Effectively Treats Brain Metastases from Breast Cancer

Written by Wang Cong Edited by Wang Duoyu Formatted by Shui Chengwen Breast cancer has the highest incidence rate among malignant tumors in women, thus it is referred to as the “pink killer.” According to the global cancer burden data released by the International Agency for Research on Cancer (IARC) in 2020, breast cancer has … Read more