AlphaFold

BindCraft: A One-Shot Protein Design Tool for Functional Protein Binders (Nature 2025)

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BindCraft: A One-Shot Protein Design Tool for Functional Protein Binders (Nature 2025)

BindCraft is a new computational tool designed for the one-shot method of creating functional protein binders. https://www.nature.com/articles/s41586-025-09429-6 Here are some key points from the paper: [Apologies for the long delay in updates] What is BindCraft? BindCraft is an open-source, automated one-stop protein binder design process aimed at simplifying the de novo design of protein binders. … Read more

A New Tool for Protein Complex Research: Foldseek-Multimer

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A New Tool for Protein Complex Research: Foldseek-Multimer

Introduction Protein complexes are key molecules that perform complex functions within cells. Understanding the structure of these complexes not only helps to reveal their functional mechanisms but also provides new ideas for drug development and disease treatment. However, with the deepening of research, the number and complexity of protein complexes have increased dramatically, and how … Read more

MultiFOLD2 and ModFOLDdock2: New Standards for Protein Complex Structure Prediction and Quality Assessment

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MultiFOLD2 and ModFOLDdock2: New Standards for Protein Complex Structure Prediction and Quality Assessment

/ Stronger than AlphaFold3? MultiFOLD2 and ModFOLDdock2: The new kings of protein complex structure prediction and assessment! / With AlphaFold2 revolutionizing the field of protein structure prediction, the scientific community has quickly turned its attention to more complex challenges —the precise modeling of protein complexes (quaternary structures). While monomer predictions are nearly perfect, the assembly … Read more