VEGF

Pathophysiological Mechanisms of Lymph Node Metastasis Differences Between HCC and ICC: Anatomical, Molecular Biology, and Microenvironment Factors

by
Pathophysiological Mechanisms of Lymph Node Metastasis Differences Between HCC and ICC: Anatomical, Molecular Biology, and Microenvironment Factors

1. Introduction: Differences in Metastasis of Malignant Liver Tumors Primary liver cancer is the third leading cause of cancer-related deaths worldwide, with hepatocellular carcinoma (Hepatocellular Carcinoma, HCC) and intrahepatic cholangiocarcinoma (Intrahepatic Cholangiocarcinoma, ICC) being the two main histological types, accounting for approximately 75%-85% and 10%-15% of primary liver cancer cases, respectively 1. Although both malignancies … Read more

Strange ADC Targets, Complex MoA, and Exhausted Bioassays

by
Strange ADC Targets, Complex MoA, and Exhausted Bioassays

When writing the previous article “TCE, Structure and Function, Bioassay Design,” I remained firmly in the “silent Fc” camp regarding TCE molecules. I wrote: For the new TCE molecules, it is generally preferred to choose a structural design with a silent Fc segment. By incorporating the Fc segment design, one can gain the advantage of … Read more