Therapeutic Index

The Development History of ADC Over 40 Years (Part 2)

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The Development History of ADC Over 40 Years (Part 2)

Key Components and Mechanisms of ADC Stability The instability of linkers in the bloodstream (also known as premature payload release) is a major factor limiting the therapeutic index of ADCs. Stabilization technologies are strategies to improve the therapeutic window. If the drug cannot be linked to the ADC, it cannot be delivered directly to tumor … Read more

Introduction to Antibody-Drug Conjugates (ADC)

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Introduction to Antibody-Drug Conjugates (ADC)

Antibody-drug conjugates (ADCs) are formed by linking monoclonal antibodies (mAbs) with small molecule drugs through linkers. The specificity of mAbs for tumor cells allows small molecule drugs to act effectively within tumor tissues, significantly reducing the high toxic side effects of traditional small molecule drugs and enhancing overall therapeutic efficiency. Currently, there are 13 ADC … Read more