Structural Biology

Structural Basis of High-Precision Protein Ligation and Its Application

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Structural Basis of High-Precision Protein Ligation and Its Application

Author Click HereLanFollow Us Hello everyone, the article we are pushing today is titled “Structural Basis of High-Precision Protein Ligation and Its Application,” published in the Journal of the American Chemical Society in January 2025. Enzyme-catalyzed protein modifications have become extremely valuable in various applications, outperforming chemical methods in terms of precision, coupling efficiency, and … Read more

Breakthrough in Alzheimer’s Disease Research! MR-SPI Crushes IVW with ‘Voting Rules’

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Breakthrough in Alzheimer's Disease Research! MR-SPI Crushes IVW with 'Voting Rules'

1 Introduction This introduction discusses the pathological complexity of Alzheimer’s Disease (AD) and the limitations of traditional research methods, gradually leading to the technical innovations and scientific significance of the study. 1.1 Disease Background and Clinical Needs • Epidemiological Data: AD accounts for 60%-70% of global dementia cases, with an estimated 152 million patients by … Read more

Proteus: An Algorithm for Stable Mutations Based on Known Protein 3D Structures

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Proteus: An Algorithm for Stable Mutations Based on Known Protein 3D Structures

Hello everyone, today I will share an article published in BMC Bioinformatics. The corresponding authors of the article are Associate Professor Raquel C. de Melo-Minardi, Dr. Ronaldo A. P. Nagem, and Dr. Diego Mariano from Universidade Federal de Minas Gerais, Brazil. The study of the effects of protein mutations may help to better alter the … Read more