Computational Biology

Nature | Open-source and Automated De Novo Protein Binder Design Process

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Nature | Open-source and Automated De Novo Protein Binder Design Process

Written by | Lin WuyuThe biological functions of proteins often depend on complex protein-protein interactions (PPIs), thus the ability to design specific protein binders that regulate these interactions holds great potential for therapeutic and biotechnological applications. Traditional methods such as immunization, antibody library screening, and directed evolution can produce binders, but they are often cumbersome, … Read more

Is Python Being Abandoned by the Academic Community? Scientists May Have Found a Better Alternative

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Is Python Being Abandoned by the Academic Community? Scientists May Have Found a Better Alternative

Some scientists have begun using a new programming language that outperforms Python, which, like Python, can be “immediately usable” and has even greater computational power. This article is reprinted from the WeChat public account “Nature Portfolio” Original author: Jeffrey M. Perkel In 2015, bioinformatician Johannes Köster was, in his own words, “almost full-time writing Python.” … Read more

MATLAB Skills and Techniques: Vectorized Computation

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MATLAB Skills and Techniques: Vectorized Computation

MATLAB is short for Matrix Laboratory and is an environment based on matrix operations. All data in MATLAB is stored in the form of matrices or multidimensional arrays. Vectors and scalars are two special forms of matrices. A vector refers to a matrix with a single row or a single column, and it is the … Read more

Proteus: An Algorithm for Stable Mutations Based on Known Protein 3D Structures

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Proteus: An Algorithm for Stable Mutations Based on Known Protein 3D Structures

Hello everyone, today I will share an article published in BMC Bioinformatics. The corresponding authors of the article are Associate Professor Raquel C. de Melo-Minardi, Dr. Ronaldo A. P. Nagem, and Dr. Diego Mariano from Universidade Federal de Minas Gerais, Brazil. The study of the effects of protein mutations may help to better alter the … Read more