pyridine

Skeletal Editing Strategy from Pyridine to Pyridazine by Sungwoo Hong at KAIST

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Skeletal Editing Strategy from Pyridine to Pyridazine by Sungwoo Hong at KAIST

The Korea Advanced Institute of Science and TechnologySungwoo Hong and his team reported a direct skeletal editing strategy that succinctly converts pyridine to pyridazine by replacing carbon atoms with nitrogen atoms. This practical method demonstrates broad functional group tolerance, allowing the transformation of various complex molecules and commercially available drugs into their biologically equivalent pyridazine … Read more

Overcoming the Challenge of Meta-Methylation of Pyridine: A Cost-Effective Aldehyde-Catalyzed Strategy Brings New Breakthroughs

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Overcoming the Challenge of Meta-Methylation of Pyridine: A Cost-Effective Aldehyde-Catalyzed Strategy Brings New Breakthroughs

Image source: J. Am. Chem. Soc.Introduction:The introduction of methyl groups can significantly enhance the activity of drugs, thus driving the development of various methylation strategies. Among these, C-H methylation is particularly noteworthy, but a universal method for meta-C-H methylation of pyridine—one of the most common nitrogen-containing heterocycles in pharmacophores—remains absent. This article reports a method … Read more