Immunogenicity of ADC Drugs
Introduction Protein drugs have the potential to induce immunogenicity, which can affect efficacy and even jeopardize life. New models of biotherapy, such as antibody-drug conjugates (ADC), fusion proteins, and pegylation, carry non-native human protein sequences and/or structural motifs, which may increase their immunogenicity risk. Therefore, comprehensive risk assessments, strategies, and analyses are needed to monitor … Read more
