Biodegradable Linkers

Electronic Tattoos for the Heart: Biodegradable Strain Sensors for Real-Time Detection of Myocardial Infarction

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Electronic Tattoos for the Heart: Biodegradable Strain Sensors for Real-Time Detection of Myocardial Infarction

Click the blue text to follow us for regular updates. 01 Article Introduction This article is a collaborative effort by research teams from Fudan University, Dalian University of Technology, and Peking University. It presents a novel ultrathin crystalline silicon-based omnidirectional strain sensor designed for implantable/wearable dynamic monitoring of soft tissue biomechanics in multiple directions. The … Read more

Rust 1.90 Introduces Workspace Publishing Support for Cargo

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Rust 1.90 Introduces Workspace Publishing Support for Cargo

Abstract: Rust developers can now automatically publish all crates in a workspace in the correct order without manually sorting individual releases. Dear developers, the Rust language release team has announced Rust 1.90, an update to the widely popular memory-safe programming language, which brings native support for workspace publishing to the Cargo package manager.Rust 1.90 also … Read more

Precise Coupling Mechanism of ADC Linkers and Crosslinkers: Targeted Release and Structural Regulation

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Precise Coupling Mechanism of ADC Linkers and Crosslinkers: Targeted Release and Structural Regulation

Linkers N – hydroxysulfosuccinimide sodium salt,FL-TPD and others possess high reactivity and cleavable characteristics, allowing them to specifically bind to antibodies and drug molecules under mild conditions, forming stable connections. In specific in vivo environments, linkers can precisely release drugs, ensuring the targeted action of ADC drugs. Protein crosslinkers such as glutaraldehyde and azide– PEG … Read more

Development of Antibody-Drug Conjugates (ADCs): Payloads, Linkers, Antibodies, and Artificial Intelligence

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Development of Antibody-Drug Conjugates (ADCs): Payloads, Linkers, Antibodies, and Artificial Intelligence

Antibody-drug conjugates (ADCs) are rapidly emerging as a transformative approach in cancer treatment, due to their potential for targeted therapy, fewer side effects, broader application, and higher therapeutic index compared to traditional chemotherapy.While ADCs initially focused on hematological malignancies, there has been a clear shift towards solid tumor treatment, with approximately 90% of ADC trials … Read more

Antibody-Drug Conjugates (ADC) – A Review of Linkers (Including a List of Commonly Used Biodegradable Linkers)

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Antibody-Drug Conjugates (ADC) - A Review of Linkers (Including a List of Commonly Used Biodegradable Linkers)

[Image] Antibody-drug conjugates (ADCs) are a class of emerging anti-cancer drugs that can directly deliver highly cytotoxic molecules to cancer cells. To date, 12 ADC drugs have received market approval. ADCs are formed by the covalent linkage of monoclonal antibodies and cytotoxins through linkers. Research indicates that linkers play a crucial role in ADC drugs, … Read more