bio-conjugation

Branch Linkers for ADCs: What Length is Appropriate?

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Branch Linkers for ADCs: What Length is Appropriate?

Selecting different lengths of branched amino triazole linkers for site-specificMTGase-mediated antibody modification, followed by strain-promoted azide-alkyne cycloaddition (SPAAC) for payload coupling. For the payload portion, clinically validated monomethyl auristatin E (MMAE) was used, coupled with hydrophilic EGCit linkers, resulting in homogeneous ADC I (DAR 2) and ADC II/III (DAR 6).At the same time, ADC IV … Read more

Not So Bioorthogonal Chemistry

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Not So Bioorthogonal Chemistry

Bioorthogonal chemistry provides powerful tools for the selective labeling of biomolecules within complex biological systems, greatly advancing research in areas such as complex cellular processes, protein dynamics, and protein interactions. However, the development of bioorthogonal chemistry still faces numerous challenges. In February 2025, Dr. Dominik Schauenburg and Professor Tanja Weil from the Max Planck Institute … Read more