chemical selectivity

Organocatalytic Meta-C-H Hydroxylation of Azaarene N-Oxides by the Team of Hua Wu at Shanghai Jiao Tong University

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Organocatalytic Meta-C-H Hydroxylation of Azaarene N-Oxides by the Team of Hua Wu at Shanghai Jiao Tong University

The team of Hua Wu at Shanghai Jiao Tong University utilizes inexpensive and readily available N–methylacetamide and oxalyl chloride in situ to generate a nitrilium ion that acts as an efficient organic catalyst, facilitating various nitrogen-containing aromatic nitroxides to undergo a stepwise, formally1,3-oxygen atom transfer process, resulting in the corresponding3-hydroxylated derivatives with high chemical and … Read more

Opening New Pathways for Peptide Modification: Direct Editing of Cysteine Side Chains to Electrophilic Alkyl Halides

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Opening New Pathways for Peptide Modification: Direct Editing of Cysteine Side Chains to Electrophilic Alkyl Halides

Hello everyone, this week I am sharing an article published in JACS titled “Direct Editing of Cysteine to Electrophilic Alkyl Halides in Peptides”. The corresponding authors are Professor Jacob M. Goldberg from Colgate University and Professor Fang Wang from the University of Rhode Island, whose research group focuses on peptide chemical modifications and bioorthogonal reactions. … Read more

Not So Bioorthogonal Chemistry

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Not So Bioorthogonal Chemistry

Bioorthogonal chemistry provides powerful tools for the selective labeling of biomolecules within complex biological systems, greatly advancing research in areas such as complex cellular processes, protein dynamics, and protein interactions. However, the development of bioorthogonal chemistry still faces numerous challenges. In February 2025, Dr. Dominik Schauenburg and Professor Tanja Weil from the Max Planck Institute … Read more