ACS Nano | Organic Radiotherapy Sensitizers with AIE Characteristics Achieve Tumor Ablation through Synergistic Induction of Apoptosis and Immunogenic Cell Death

ACS Nano | Organic Radiotherapy Sensitizers with AIE Characteristics Achieve Tumor Ablation through Synergistic Induction of Apoptosis and Immunogenic Cell Death

Inspired by the clinical enhancement of radiotherapy efficacy through hyperthermia, this study demonstrates a pure organic nanoparticle’s multimodal diagnostic application in tumor combination therapy, integrating imaging and photothermal properties. This nanoparticle possesses various unique characteristics and functions, including excellent photostability and thermal stability, strong fluorescence emission in the near-infrared II (NIR-II) region, extremely high photothermal … Read more

Thiophene π-Bridge Manipulation of NIR-II AIEgens for Multimodal Tumor Phototheranostics

Thiophene π-Bridge Manipulation of NIR-II AIEgens for Multimodal Tumor Phototheranostics

Fu Rui Sen Na Mi N A N O NIR-Ⅱ FLI Thiophene π-Bridge Manipulation of NIR-II AIEgens for Multimodal Tumor Phototheranostics Journal:Angewandte Chemie-International Edition, IF=16.1 Pub Date:2024-02-12 First Author:Yixiong Gui, Yuanwei Wang, Deliang Wang Corresponding Authors:Dingyuan Yan*, Ben Zhong Tang*, and Dong Wang* Corresponding Author Institution: School of Science and Engineering, Shenzhen Institute of Aggregate … Read more

Enhancing AIEgen Fluorescence Efficiency via Anion-π+ Interaction

Enhancing AIEgen Fluorescence Efficiency via Anion-π+ Interaction

Cancer poses a severe threat to human health, making the development of photosensitizers with both diagnostic and therapeutic functions significant in combating cancer. Thanks to the excellent aggregation-induced emission (AIE) efficiency and reactive oxygen species (ROS) generation capability, AIE technology shows tremendous advantages in fluorescence imaging-guided photodynamic cancer therapy (integrated diagnosis and treatment). However, the … Read more

Enhancing NIR-II AIEgens for Efficient Dual-Modal Surgical Navigation

Enhancing NIR-II AIEgens for Efficient Dual-Modal Surgical Navigation

First Author:Dr. Ma Fulong, Dr. Jia Xi, Dr. Deng Ziwei Corresponding Authors:Professor Tang Banzhong; Professor Zhao Zheng Affiliation:The Chinese University of Hong Kong (Shenzhen), School of Science and Engineering Full Text Link:https://doi.org/10.1021/acsnano.3c11078 Keywords NIR-II; Aggregation-Induced Emission; Molecular Motion; Radiative and Non-Radiative Transitions; Surgical Navigation Research Background As an emerging diagnostic technology, fluorescence imaging offers advantages … Read more