Site-Specific Coupling

Four Classic Site-Specific Coupling Technologies for ADCs

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ADCs have become a promising class of anti-tumor drugs, with over a dozen ADCs approved for treating various types of cancer patients. Traditional ADCs utilize the amino groups of antibody lysines or the thiol groups obtained from the reduction of inter-chain disulfide bonds in cysteines for coupling. However, their uniformity is poor, and stability is … Read more

Analysis of Six Classic Point-Coupling Technologies for ADC

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ADC drug conjugation refers to the method of linking various components of ADC, which determines the drug-antibody conjugation ratio (DAR) and homogeneity, affecting the drug’s activity, tolerance, and stability. It is generally divided into random coupling and site-specific coupling. Non-Site-Specific Coupling Common methods include coupling at Lys residues and Cys residues. Site-Specific Coupling, which includes … Read more