1 Introduction c-MET [also known as MET tyrosine protein kinase or hepatocyte growth factor receptor (HGFR)] is a protein encoded by the MET gene. c-MET is crucial for embryonic development, organ growth, and wound healing. Hepatocyte growth factor (HGF) is the ligand for the c-MET receptor. MET is typically expressed by epithelial-derived cells, but can … Read more
Introduction Antibody-drug conjugates (ADCs) consist of antibodies, linkers, and cytotoxic payloads. Compared to traditional chemotherapy, ADCs target tumors with the promise of reducing systemic toxicity, providing a broader therapeutic window and a higher therapeutic index. Over the past decade, ADCs have gradually matured in the treatment of solid tumors and hematological malignancies, becoming a revolutionary … Read more
Kernel Density Estimation (KDE) was first proposed by Rosenblatt and Parzen. Unlike parametric methods that assume a specific distribution and parameters in advance, this method estimates the probability distribution of indicators directly from the given data sample, thus it belongs to non-parametric methods. This method is commonly applied to estimate the probability density of random … Read more