impurity control

Semiconductor Quartz Crucibles: Who is Really Locked by Technology?

by
Semiconductor Quartz Crucibles: Who is Really Locked by Technology?

Chip manufacturing has extremely stringent requirements for the quality of raw material silicon wafers, particularly in terms of purity, defect density, dislocations, and impurity content (oxygen, carbon, metal ions). Quartz crucibles are key consumables in the production of semiconductor silicon wafer raw materials. Source: Meijing New Materials As a carrier of molten polycrystalline silicon, quartz … Read more

Challenges and Strategies in the Synthesis of ADC Drug Conjugates: A Comprehensive Analysis of ABBV-154 Process Development

by
Challenges and Strategies in the Synthesis of ADC Drug Conjugates: A Comprehensive Analysis of ABBV-154 Process Development

Keywords：ADC drug conjugates, process optimization, impurity control, synthesis, chromatographic purification, crystallization purification This article analyzes the synthesis route of ABBV-154 (an immunology ADC drug conjugate), aiming to address the low yield and multiple chromatographic purification steps of the first-generation route. Through systematic process optimization, stable production at hundreds of grams scale is achieved, providing key … Read more