Challenges and Strategies in the Synthesis of ADC Drug Conjugates: A Comprehensive Analysis of ABBV-154 Process Development
Keywords：ADC drug conjugates, process optimization, impurity control, synthesis, chromatographic purification, crystallization purification This article analyzes the synthesis route of ABBV-154 (an immunology ADC drug conjugate), aiming to address the low yield and multiple chromatographic purification steps of the first-generation route. Through systematic process optimization, stable production at hundreds of grams scale is achieved, providing key … Read more