cerebrospinal fluid biomarkers

Subcortical-Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia

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Subcortical-Cortical Functional Connectivity as a Potential Biomarker for Identifying Patients with Functional Dyspepsia

Functional Dyspepsia (FD) is a common functional gastrointestinal disorder characterized by self-reported symptoms such as upper abdominal pain, upper abdominal burning, postprandial fullness, and early satiety, which cannot be explained by routine clinical evaluations. Epidemiological studies indicate that approximately 20% of the global population suffers from dyspepsia, with 80% of these individuals lacking endoscopic evidence … Read more

Understanding TROP2 ADC: From Mechanism of Action to Clinical Efficacy

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Understanding TROP2 ADC: From Mechanism of Action to Clinical Efficacy

Abstract:TROP2 (Trophoblast Cell Surface Antigen 2) is a tumor-associated antigen that is highly expressed in various solid tumors and has become a popular target for antibody-drug conjugates (ADCs). This article systematically introduces the biological characteristics of TROP2 and its expression profile in tumors, focusing on the molecular design, mechanism of action, and clinical efficacy of … Read more

Clinical Development of ADCs for Solid Tumors: 40 Years of Progress

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Clinical Development of ADCs for Solid Tumors: 40 Years of Progress

Clinical Development of ADCs for Solid Tumors The currently approved ADCs for solid tumors are listed in the table below: ADCs Target Indications T-DM1 HER2 HER2-positive metastatic breast cancer SG (sacituzumab govitecan) Trop2 Triple-negative breast cancer (TNBC) Metastatic urothelial carcinoma (mUC) sacituzumab tirumotecan Trop2 TNBC, NSCLC Gastric cancer/gastroesophageal junction cancer, mUC enfortumab vedotin Nectin-4 Locally … Read more

The Dawn of Dementia Care: When AI Robots Enter Fudan Memory Clinic

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The Dawn of Dementia Care: When AI Robots Enter Fudan Memory Clinic

Introduction: Behind the Disappearance of Memory: How Will You Accompany Your Mother? Have you ever had moments like this? Your originally gentle and determined mother suddenly puts her keys in the refrigerator or carelessly piles the washed clothes on the coffee table. You go from initial jokes and teasing to an increasingly heavy sense of … Read more