Following a series of DAC transactions last year, interest in this area has gradually increased, leading to various discussions and reviews. Among the products in the clinical phase of DAC, AbbVie‘s product ABBV-787 frequently appears alongside ORM-5029 and ORM-6151, but unlike the latter two, ABBV-787 has never disclosed any technical details in public forums. Although … Read more
Introduction Degrader-Antibody Conjugates (DAC) are a novel entity that combines the payload of Protein Degradation Targeting Chimeras (PROTAC) with monoclonal antibodies through a type of chemical linker (DAC =PROTAC + ADC). This article collects several examples of DAC from scientific and patent literature and documents specific challenges associated with DAC construction. Overall, these examples indicate … Read more
【Research Background】 The performance decay of lithium-ion batteries (LIBs) is influenced by both cycling and storage. The performance decay caused by cycling is primarily due to the chemical-mechanical degradation of active materials, which has been extensively studied. However, the mechanisms of performance decay due to storage differ from those due to cycling, and research on … Read more