Targeting the ‘Activated State’ KRAS: Discovery of the Highly Cooperative PROTAC Degrader ACBI4
Hello everyone, this week I am sharing an article published in JACS titled “Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles.” The corresponding authors are Professors Alessio Ciulli and Kirsten McAulay from the University of Dundee, along with Peter Ettmayer from Boehringer Ingelheim. Their research primarily focuses on the mechanism of action … Read more