base-induced degradation

Targeting the ‘Activated State’ KRAS: Discovery of the Highly Cooperative PROTAC Degrader ACBI4

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Targeting the 'Activated State' KRAS: Discovery of the Highly Cooperative PROTAC Degrader ACBI4

Hello everyone, this week I am sharing an article published in JACS titled “Identification of a Highly Cooperative PROTAC Degrader Targeting GTP-Loaded KRAS(On) Alleles.” The corresponding authors are Professors Alessio Ciulli and Kirsten McAulay from the University of Dundee, along with Peter Ettmayer from Boehringer Ingelheim. Their research primarily focuses on the mechanism of action … Read more

Base-Induced N-Terminal Peptide Sequencing Method

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Base-Induced N-Terminal Peptide Sequencing Method

Hello everyone, today I would like to share an article published in JACS: After 75 Years, an Alternative to Edman Degradation: A Mechanistic and Efficiency Study of a Base-Induced Method for N‑Terminal Peptide Sequencing. The corresponding authors are Professors Eric V. Anslyn and Edward M. Marcotte from the University of Texas at Austin. Professor Anslyn’s … Read more