Spinocerebellar Ataxias (SCAs) are a group of autosomal dominant hereditary neurodegenerative diseases with an incidence of 1-5 cases per 100,000 globally. With advancements in molecular biology, 49 subtypes have been identified based on genetic diagnosis. This disease exhibits significant regional and genetic heterogeneity, with varying proportions of subtypes in different regions. In the mainland Chinese … Read more
Written by | Qi Edited by | Yan Utilizing neuronal regeneration to treat neurodegenerative diseases remains a key challenge in the field of regenerative medicine. The direct conversion of local glial cells into neurons has become a viable alternative to replace functional neurons【1,2】. Considering that the increase in reactive oxygen species generation significantly hinders the … Read more
Recently, a study published in the international journal Applied Physiology, Nutrition, and Metabolism by researchers from the University of Guelph found that exercise may potentially reduce the toxic accumulation of glutamate in the brain, while also decreasing the severity of various brain disorders, such as Huntington’s disease. Glutamate is an amino acid that forms proteins, … Read more