CRISPR/Cas12a

RNA-Activated CRISPR/Cas12a Nanorobots Operating in Live Cells

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RNA-Activated CRISPR/Cas12a Nanorobots Operating in Live Cells

Abstract The active clustered regularly interspaced short palindromic repeats (CRISPR/Cas12a) system possesses cis-cleavage (targeting) and trans-cleavage (off-target) activities, which are highly useful for genome engineering and diagnostic applications. Both single-stranded and double-stranded DNA can activate crRNA−Cas12a ribonucleoprotein (RNP), enabling its cis and trans cleavage enzymatic activities. However, whether RNA can activate the CRISPR/Cas12a system and … Read more

Professor Jia Ning from Southern University of Science and Technology Publishes Two Papers in Science in One Week

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Professor Jia Ning from Southern University of Science and Technology Publishes Two Papers in Science in One Week

On May 1, 2025, the Jia Ning team from Southern University of Science and Technology published an article in Science, achieving significant results in the field of phage research. She obtained her PhD fromUniversity of Science and Technology of China, School of Life Sciences (supervisors: Professors Zhou Congzhao and Chen Yuxing), and completed her undergraduate … Read more

Detection of FTO Using a DNAzyme-Mediated CRISPR/Cas12a Signal Amplification Electrochemiluminescence Biosensor with C-CN/PCNV Heterojunction as Emitter

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Detection of FTO Using a DNAzyme-Mediated CRISPR/Cas12a Signal Amplification Electrochemiluminescence Biosensor with C-CN/PCNV Heterojunction as Emitter

Click the blue text Follow us Introduction /Introduction Fat mass and obesity-associated protein (FTO) is the first identified m6A demethylase, and its abnormal expression is associated with various cancers such as acute myeloid leukemia, melanoma, cervical cancer, and breast cancer. Developing highly sensitive and selective methods for FTO detection is crucial for early cancer diagnosis … Read more