C-Reactive Protein: A Sensitive Marker of Inflammation

C-Reactive Protein: A Sensitive Marker of Inflammation

C-Reactive Protein C-Reactive Protein (CRP), discovered by Tillett and Francis in 1930, is a pentameric protein synthesized by the liver. During acute inflammation or infection, CRP levels rise significantly, primarily induced by interleukin-6 (IL-6), playing an important regulatory role in the acute phase of inflammation/infection processes. The CRP level in healthy individuals is usually very … Read more

Interpretation of Combined Insulin and C-Peptide Test Results

Interpretation of Combined Insulin and C-Peptide Test Results

Common Patterns Insulin CPep Clinical Significance ↑↑ ↑↑ Insulinoma, insulin resistance (early stage of type 2 diabetes) ↑↑ ↓↓ Exogenous insulin use (artificial hypoglycemia) ↓↓ ↓↓ Type 1 diabetes, late stage type 2 diabetes Normal ↑↑ Insulin resistance (compensatory secretion increase) Assessment of Insulin Resistance Normal value: <2.5; >2.9 indicates insulin resistance. Interfering Factors and … Read more