Interpretation of Combined Insulin and C-Peptide Test Results

Interpretation of Combined Insulin and C-Peptide Test ResultsCommon Patterns

Insulin

CPep

Clinical Significance

↑↑

↑↑

Insulinoma, insulin resistance (early stage of type 2 diabetes)

↑↑

↓↓

Exogenous insulin use (artificial hypoglycemia)

↓↓

↓↓

Type 1 diabetes, late stage type 2 diabetes

Normal

↑↑

Insulin resistance (compensatory secretion increase)

Interpretation of Combined Insulin and C-Peptide Test ResultsAssessment of Insulin ResistanceInterpretation of Combined Insulin and C-Peptide Test Results

Normal value: <2.5; >2.9 indicates insulin resistance.

Interpretation of Combined Insulin and C-Peptide Test ResultsInterfering Factors and PrecautionsTiming of testing: Fasting or postprandial state must be clearly indicated (postprandial C-peptide is more sensitive in reflecting β-cell reserve).Drug effects: Sulfonylureas stimulate endogenous insulin secretion → insulin ↑ + C-peptide ↑.Insulin injection → insulin ↑ + C-peptide ↓.Sample handling: Avoid hemolysis (affects insulin testing), store at low temperatures (C-peptide is more stable).This article is sourced from: Testing Starry Sky, the views expressed do not represent the platform’s views, and are for public welfare promotion of science, please contact for deletion if there is infringement!

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