From Single Target to Multidimensional Breakthrough: The New Landscape and Strategic Evolution of Next-Generation ADC Drug Bioanalysis

From Single Target to Multidimensional Breakthrough: The New Landscape and Strategic Evolution of Next-Generation ADC Drug Bioanalysis

With the breakthrough progress of novel structures such as bispecific ADCs and dual payload ADCs, ADC drugs have transitioned from “single-target precision strikes” to a new era of “multidimensional collaborative operations.” These innovative designs greatly expand therapeutic potential but also make their molecular structures, mechanisms of action, and in vivo fates unprecedentedly complex. In this … Read more

17th GCC Closed Forum: Cutting-edge Topics in Bioanalysis and Global Consensus

17th GCC Closed Forum: Cutting-edge Topics in Bioanalysis and Global Consensus

On May 10, 2024, the Global CRO Council for Bioanalysis (GCC) successfully held the 17th Closed Forum in San Antonio, USA. This forum brought together representatives from international bioanalytical contract research organizations (CROs) to discuss scientific and regulatory issues in the field of bioanalysis. The meeting covered eleven major topics, including integrative bioanalysis, patient-centric sampling, … Read more

Biological Analysis of ADC Drugs Using LC-MS/MS

Biological Analysis of ADC Drugs Using LC-MS/MS

LC-MS/MS ADC Drug Biological Analysis A Dual Advantage in Speed and Cost 0 1 Definition of Antibody-Drug Conjugates (ADC) Antibody-drug conjugates (ADC) consist of an antibody, a cytotoxic drug, and a linker (as shown in Figure 1[1]), and are considered an innovative therapeutic approach targeting various types of tumors and cancers. They can enhance the … Read more