Please click the “Bio New Thinking” above to follow more exciting content! Written by / Jia Bei Pharmaceutical @ Bai Ao Yun Testing Reviewed by / Gu Du Pharmacist @ Bio New Thinking Antibody-drug conjugates (ADCs) are large molecule drugs formed by conjugating monoclonal antibodies with highly potent small molecule drugs via linkers, enabling targeted … Read more
Breast cancer, regarded as the “killer of beauty,” is a malignant tumor that severely threatens women’s health, with an increasing incidence year by year. Antibody-drug conjugates (ADC), as a new type of therapeutic drug, have become a hot research topic in the field of breast cancer due to their advantages of “high efficacy and low … Read more
Introduction Antibody-drug conjugates (ADCs) are “biological bullets” formed by conjugating cytotoxic drugs (payloads) to antibodies via a “linker.” They consist of five components: target, antibody, linker, payload, and conjugation method. Each part is crucial to the function of ADCs, but today we will focus on the linker that connects the antibody and payload, examining the … Read more
Since the first use of cytotoxic chemicals to treat cancer, oncologists have been searching for ways to enhance efficacy without significantly increasing overall toxicity to patients. One of the methods attempted to improve the killing effect on tumor cells is the use of cytotoxic agents with potency at picomolar or lower levels (such as microtubule … Read more
History of ADC Drug Development Phase 1 (1906-1982), the concept of targeted therapy was proposed, and the technology took shape. Phase 2 (1983-2011), transition from clinical trials to commercialization, Mylotarg® was approved for market. Phase 3 (2012-present), explosive growth of ADC products. The five key elements of ADC drugs are target, antibody, linker, cytotoxic agent, … Read more
When learning about fire alarm systems, many people encounter the professional terms “Two-Wire Bus”, “Two-Wire System”, and “Four-Wire System”. So, what do they mean? What are the differences and application scenarios? Today, we will quickly clarify these common concepts! 1. Starting from the basics: Where do the Two-Wire Bus, Two-Wire System, and Four-Wire System come … Read more
1. Fill in the blanks with the appropriate form of the words in parentheses. 1. I can’t (play) basketball with you. I have too much homework to do. 2. – Can your parents (speak) English? -Yes, they can. 3. What can your sister (do)? 4. Can you (swim) in the swimming pool with us on … Read more
Modal verbs have specific meanings, but like auxiliary verbs, they need to be combined with other words to form the predicate of a sentence. Additionally, modal verbs do not change according to person or number, and they must be followed by the base form of a verb. To help students better understand, Teacher Wang has … Read more
Point 1: The Usage of Modal Verbs Can, May, Must in Statements: 1. Usage of can: (1) Indicates ability, permission, and possibility. When indicating ability, it is generally translated as “can” or “be able to”, meaning having a certain ability, especially an innate ability. For example: She can swim fast, but I can’t. I can … Read more
1. Synchronous and Asynchronous Transmission 1.1 Concepts and Examples Using everyday examples to illustrate what synchronous and asynchronous mean: Synchronous: A friend calls to say they are coming to my house for dinner, and I wait for them at home. Asynchronous: A friend arrives at my house unexpectedly without prior notice. The difference lies in … Read more