To improve the DMPK characteristics, many studies have explored the coupling of PROTAC payloads with monoclonal antibodies to create a new molecule known as “Antibody-Drug Conjugates (DAC).” This allows for more effective delivery of PROTAC degraders in vivo. ▲ Structure of DAC (Image Source: Reference 1) Compared to PROTAC molecules, DAC has several potential advantages: … Read more
1. Introduction Today, I derived the output formula for an 8-bit resistor DAC, calculating the impact of the microcontroller’s IO port resistance on the DAC’s linear accuracy. Now that I have some time left, I will patiently derive the analytical formula for the output voltage of a 15-bit DAC to verify whether the microcontroller’s IO … Read more
What are ABC, ABD, ABS, ASR, BAS, DAC, DSC, EBA, EBD, EDS, ESP? Do you think they are just simple English letters? It’s not that simple in the automotive world. Today, we will give you a comprehensive interpretation. ABC——Active Body Control System The ABC system allows for quicker and more precise control of the car’s … Read more
The International Energy Agency (IEA) recently released a report on “Direct Air Capture” which highlights the increasing significance of Direct Air Capture (DAC) technology in achieving net zero pathways. Capturing carbon dioxide directly from the air and permanently sequestering it not only reduces atmospheric CO2 but also provides a solution for residual emissions while serving … Read more
To deliver chemotherapy drugs more effectively, small molecule drug conjugates (SMDC), antibody-drug conjugates (ADC), and degrader-antibody conjugates (DAC) have been explored and developed, providing selective delivery while improving the therapeutic index. What are their similarities and differences? What are their respective advantages? What is the current state of research? What does the future hold? This … Read more
High-Performance Digital-to-Analog Converter (DAC) Chip Technology 01. Overview of Achievements The Digital-to-Analog Converter (DAC) is essential for converting digital signals into analog signals, making it a core general-purpose chip. High-speed, high-precision DACs are widely used in broadband communications, especially in high-performance military and civilian applications such as radar and 5G communications. High-performance data converters can … Read more
In electronic design, the layout and routing of Analog-to-Digital Converters (ADC) and Digital-to-Analog Converters (DAC) are key factors affecting system performance. Proper routing can not only improve signal quality and reduce noise interference but also optimize the overall performance of the system. 1. Pre-define Routing Areas 2. Separate Analog and Digital Signals 3. Optimize the … Read more
The Emergence and Advantages of DAC Cancer therapeutics need to achieve a balance between efficacy and safety, even targeted chemotherapy does not always only kill abnormal cancer cells, non-specific toxicity can lead to a low therapeutic index and side effects. The technology of proteolysis-targeting chimeras (PROTACs), which achieves therapeutic effects by promoting the degradation of … Read more
Introduction Degrader-Antibody Conjugates (DAC) are a novel entity that combines the payload of Protein Degradation Targeting Chimeras (PROTAC) with monoclonal antibodies through a type of chemical linker (DAC =PROTAC + ADC). This article collects several examples of DAC from scientific and patent literature and documents specific challenges associated with DAC construction. Overall, these examples indicate … Read more
DAC (Digital-to-Analog Converter) and ADC (Analog-to-Digital Converter) are essential components for converting between digital and analog signals, widely used in electronic systems for various applications such as digital signal processing, data acquisition, and control. So, do you know how to implement DAC and ADC? Methods for Implementing DAC 1. Resistor Network A resistor network is … Read more