Zeng Linghui’s Research Group at the Medical School Reveals the Mechanism by which Somatostatin Interneurons (SOM-INs) Regulate Excitatory Synapses through Astrocytic Purinergic Signaling
01 Introduction Research has confirmed that GABAergic neurons regulate synaptic excitability by activating presynaptic GABAB receptors (GABABRs). However, recent studies have shown that astrocytes also express GABABRs and can respond to the activity of GABAergic neurons. Nevertheless, it has been challenging for researchers to distinguish or overlook whether astrocytic GABABRs are involved in the mechanisms … Read more