GABAergic Neurons

Zeng Linghui’s Research Group at the Medical School Reveals the Mechanism by which Somatostatin Interneurons (SOM-INs) Regulate Excitatory Synapses through Astrocytic Purinergic Signaling

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Zeng Linghui's Research Group at the Medical School Reveals the Mechanism by which Somatostatin Interneurons (SOM-INs) Regulate Excitatory Synapses through Astrocytic Purinergic Signaling

01 Introduction Research has confirmed that GABAergic neurons regulate synaptic excitability by activating presynaptic GABAB receptors (GABABRs). However, recent studies have shown that astrocytes also express GABABRs and can respond to the activity of GABAergic neurons. Nevertheless, it has been challenging for researchers to distinguish or overlook whether astrocytic GABABRs are involved in the mechanisms … Read more

Scientists Reveal Reward Learning Pathway Mediated by Somatostatin Neurons

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Scientists Reveal Reward Learning Pathway Mediated by Somatostatin Neurons

Assessing the positive or negative valence of external sensory cues and translating them into appropriate behavioral responses is crucial for animal survival in complex or challenging environments. Negative valence signals lead to aversive/avoidance behaviors, while positive valence signals promote reward/approach behaviors. Much previous research has focused on the neural structures within the emotional processing network … Read more

Overview and Lecture: Research Progress on the Correlation Between Cholecystokinin and Depression

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Overview and Lecture: Research Progress on the Correlation Between Cholecystokinin and Depression

Abstract Depression is a mental disorder characterized by significant and persistent low mood. Recent studies have found that cholecystokinin (CCK), a small molecule brain-gut peptide (BGP), is widely distributed in the central nervous system (CNS) and the enteric nervous system (ENS). To clarify the relationship between CCK and the pathogenesis of depression, this article reviews … Read more