The Comeback of Inert Esters: Samarium(II) Iodide Mediated Radical 1,4-Ester Migration
Image source: J. Am. Chem. Soc.Introduction: Samarium(II) iodide (SmI₂,Kagan reagent) mediated reduction cyclization reactions of carbonyl compounds provide an important platform for stereocontrolled construction of complex molecular structures. In addition to traditional ketone and aldehyde substrates, recent advances in radical chemistry have enabled lactones and lactams to undergo cyclization via SmI₂. However, acyclic ester compounds … Read more