Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection

◆ ◆ ◆ ◆ Sci Adv | Development of uCoTargetX Technology for Single-Cell Multi-Protein Modification and Transcription Detection Technological innovation is a crucial engine for modern life sciences research. Each iteration and update of biotechnology brings disruptive changes to the life sciences field. In recent years, single-cell sequencing technology has developed rapidly, propelling scientists worldwide … Read more

Understanding The Mechanism of Immune Response Triggered by Different Lipid Components in Lipid Nanoparticles (LNP)

Understanding The Mechanism of Immune Response Triggered by Different Lipid Components in Lipid Nanoparticles (LNP)

Note: This article does not constitute any investment opinion or advice, and should be based on official/company announcements; it is only intended for the introduction of medical and health-related drugs and does not represent treatment recommendations (if involved), nor does it represent the position of Yao Hai Biotechnology. Any reproduction of this article requires authorization. … Read more

How Dipole Moment Affects Lithium Metal Anodes

How Dipole Moment Affects Lithium Metal Anodes

First Author: Li Pengcheng Corresponding Author: Li Ge Affiliation: University of Alberta, Canada [Research Background] Current lithium-ion batteries rely on intercalation chemistry, achieving an energy density of about 250 Wh kg-1. However, there is a continuous demand for higher energy density (500 Wh kg-1), especially for electric vehicles and even electric aircraft. One potential method … Read more

Multi-Gradient Bone-Like Nanocomposites Induced by Strain Distribution

Multi-Gradient Bone-Like Nanocomposites Induced by Strain Distribution

iNature The heterogeneity of bone is crucial for adapting to local strain environments, which is essential for maintaining mechanical function. This adaptation enables a strong correlation between strain distribution and multiple gradients, laying the foundation for creating complex gradient structures. However, the synthesis of such functionally graded materials has not been fully explored. On October … Read more

Ultrasound-Triggered NO Release for Hearing Loss Therapy

Ultrasound-Triggered NO Release for Hearing Loss Therapy

iNature Intense noise can damage the spiral ganglion neurons (SGN) in the inner ear, affecting axonal regeneration and leading to noise-induced hearing loss (NIHL). On November 19, 2024, researchers from Fudan University, Bu Wenbo, Ren Dongdong, and Liu Yanyan published a paper titled“Ultrasound-Triggered NO Release to Promote Axonal Regeneration for Noise-Induced Hearing Loss Therapy” in … Read more

The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

The Dual Role of Protein Corona in Tumor Targeting, Immunotherapy, and Diagnosis

Recently, Associate Professor Zhang Wenli’s team at China Pharmaceutical University published a review titled “The Janus of Protein Corona on Nanoparticles for Tumor Targeting, Immunotherapy and Diagnosis” in Journal of Controlled Release, Volume 345, 2022, and it was selected as the Inside Back Cover article of that issue.. Figure 1. The dual-edged effect of protein … Read more

Oxygen-Deficient Molybdenum Oxide Nanosensitizers for Ultrasound-Enhanced Cancer Metalloimmunotherapy

Oxygen-Deficient Molybdenum Oxide Nanosensitizers for Ultrasound-Enhanced Cancer Metalloimmunotherapy

Sonodynamic therapy (SDT) is a non-invasive treatment method based on reactive oxygen species (ROS) that interacts with ultrasound (US) activated sonosensitizers and surrounding oxygen and water molecules to produce highly cytotoxic ROS and induce apoptosis. Due to its ability to penetrate deep tissues while causing minimal damage to normal cells, it has significant potential in … Read more

Interpretation of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) Technology

Interpretation of Time-of-Flight Secondary Ion Mass Spectrometry (ToF-SIMS) Technology

Source: Old Thousand and His Friends Original Author: Sun Qian The Time-of-Flight Secondary Ion Mass Spectrometer has developed into a powerful micro-surface analysis application technology. This technology can be applied in areas where traditional dynamic SIMS cannot, with the following advantages: it can synchronously detect different ions over an almost unlimited mass range; it has … Read more

Cutting-Edge Sequencing Technologies: A Detailed Introduction to Single-Molecule Optical Mapping

Cutting-Edge Sequencing Technologies: A Detailed Introduction to Single-Molecule Optical Mapping

The eukaryotic genome exhibits various repetitive sequences (such as centromeres, telomeres, etc.) and long gaps, which increasingly highlight the shortcomings of existing sequencing technologies. Although second-generation sequencing technologies can cheaply generate a large amount of sequencing data, their read length limitations prevent a simple and intuitive view of structural changes across the entire genome; PacBio … Read more

P.S. Lee Team at NTU: Low-Temperature Atomic Layer Deposition Enhances Performance of Flexible Thin-Film Transistors

P.S. Lee Team at NTU: Low-Temperature Atomic Layer Deposition Enhances Performance of Flexible Thin-Film Transistors

With the development and application of microelectronics technology, flexible thin-film transistors with characteristics such as bendability, deformability, and portability have attracted extensive research in fields such as wearable health management devices and flexible displays. Flexible thin-film transistors made of metal oxides, although they have better performance and stability compared to transistors made from carbon nanotubes … Read more