Excessive reactive oxygen species, damage to the epithelial barrier, immune dysregulation, and imbalance of the gut microbiota are key factors leading to the onset of inflammatory bowel disease (IBD) and complicating its treatment. Timely diagnosis of the disease and precise delivery of therapeutic drugs to the inflamed intestinal sites is a targeted strategy that can effectively treat IBD.
In this regard, Professors Cheng Kui and Cai Xiujun from Zhejiang University have developed a barium sulfate-based nanoplatform (BaSO4@PDA@CeO2/DSP, BPCD), which is used for the synergistic delivery of nanoenzymes and drugs.
Key Points of the Article:
(1) After oral administration, the drug achieves enhanced colonic retention to precisely target the inflamed sites and facilitate CT imaging guidance, effectively addressing multiple factors contributing to IBD. The study found that the drug can achieve integrated treatment through the synergistic effect between cerium oxide with an optimal Ce3+/Ce4+ ratio and sustained-release dexamethasone sodium phosphate.
(2) Thanks to its superior gastrointestinal stability, this nanoplatform exhibits significant IBD treatment effects through mechanisms such as alleviating oxidative stress, regulating macrophage polarization balance, modulating gut microbiota composition, and repairing the epithelial barrier.
In summary, the BPCD constructed in this study can inhibit the development of IBD through multiple mechanisms and has excellent biocompatibility, making it a promising new method to replace traditional IBD treatment strategies.
References:
Yaoting He. et al. Multifunctional Double-Loaded Oral Nanoplatform for Computed Tomography Imaging-Guided and Integrated Treatment of Inflammatory Bowel Disease. ACS Nano. 2025
DOI: 10.1021/acsnano.4c18865
https://pubs.acs.org/doi/10.1021/acsnano.4c18865
Nanomaterials Custom Synthesis
Teacher Wang
198 2262 5523
Nanolab Nanomaterials Communication QQ Group: 937788022 If you want to submit your prepared materials to the nanolab platform, add the editor’s WeChat 19822625523
Note: Name – Institution – Material Name (submissions without notes will not be accepted).
