The reduction of amides is also a commonly used method for synthesizing amines, often employed for the monoalkylation of primary amines. The most common method for reducing amides to amines is through LAH under heated reflux. However, when sensitive functional groups are present within the molecule, such as halogens (especially bromine and iodine) on an … Read more
1. Introduction Acyclic compounds are important intermediates in the synthesis of many pharmaceuticals, and the synthesis of acyclic compounds is a very important part of organic synthesis. They are generally prepared by several methods: 1. Dehydration of amides 2. Reaction of aliphatic halides or sulfonate esters 3. Cyanation of aromatic halides 4. Other conversions from … Read more
Research has found that for certain iodides, some phosphine-free ligand catalysts can efficiently catalyze reactions under milder conditions, such as PdCl2, Pd(OAc)2, Pd/C, etc. At the same time, it can also avoid the impurities formed by ligands during the reaction that complicate the product separation process. Hiroa【Sakurai, H. J. Org. Chem. 2002, 67, 2721】 and … Read more