Mendelian randomization

The Relationship Between LDL-C and Mortality in Septic Shock

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The Relationship Between LDL-C and Mortality in Septic Shock

Decreased Clearance of Low-Density Lipoprotein Cholesterol is Causally Associated With Increased Mortality of Septic Shock. Takahashi, Campbell, Nakada, Walley (2025) Crit Care Med (IF: 6)1st District 1. Abstract Objective This study aims to investigate whether low-density lipoprotein cholesterol (LDL-C) levels, determined by the balance of clearance and production, causally contribute to the increased 28-day mortality … Read more

Southeast University and Jiangnan University Teams Discover Interoceptive Neural Circuits as Shared Pathways for Comorbid Depression in Various Somatic Diseases

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Southeast University and Jiangnan University Teams Discover Interoceptive Neural Circuits as Shared Pathways for Comorbid Depression in Various Somatic Diseases

AbstractDepressive disorders are among the most common mental illnesses globally, with over 40% of patients with chronic somatic diseases also exhibiting depressive symptoms, significantly increasing the burden of disease and affecting treatment outcomes.Increasing research indicates that factors such as chronic inflammation, metabolic disorders, and blood flow disturbances can induce depression by damaging the central nervous … Read more