AKT1

JBC | Dentin Sialophosphoprotein (DSP) Acts as an Angiogenic Factor through Endoglin

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JBC | Dentin Sialophosphoprotein (DSP) Acts as an Angiogenic Factor through Endoglin

Dentin sialophosphoprotein (DSPP) is highly expressed in odontoblasts responsible for dentin formation. Traditionally, DSPP is considered an extracellular matrix protein that regulates the formation and mineralization of dentin matrix. In Dspp knockout mice, in addition to defects in dentin formation, researchers observed a phenotype of reduced angiogenesis in certain regions of the femur. However, the … Read more

Professor Zhang Jianzhong’s Guide To Acne Along Blaschko Lines In Proteus Syndrome

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Professor Zhang Jianzhong's Guide To Acne Along Blaschko Lines In Proteus Syndrome

Expert Guide Proteus syndrome, also known as deformation syndrome, is a genetic disorder caused by a mutation in the AKT1 gene, leading to progressive and asymmetric overgrowth of the skin, soft tissues, bones, and internal organs. The skin manifestations are an important component of deformation syndrome, which includes cerebriform connective tissue nevi, epidermal nevi, lipomatous … Read more