New Horizons in C–H Bond Halogenation Technology: A Practical Ligand Facilitating Efficient Halogenation of Aromatic Rings
Image source: J. Am. Chem. Soc.Introduction: After more than half a century of development, ortho-halogenated aromatic compounds—widely used in cross-coupling reactions—are primarily synthesized and produced through stoichiometric directed ortho-lithiation/halogenation techniques. Although catalytic C–H bond halogenation has emerged as a potentially environmentally friendly method, the requirement for stoichiometric bases, expensive oxidants, and directing group installation has … Read more